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This adaptability allows the heart to regulate the utilization of different energy substrates according to its needs, maintaining normal cardiac function and ensuring a continuous supply of ATP (34, 50)

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Further validation of the proposed mechanism was emphasized with absence of Gcg/T3-mediated effects in global GcgR knockout mice and mice with a liver-specific deletion of thyroid hormone receptor B [54]

Large clinical trials have demonstrated their effectiveness, and they are now increasingly prescribed for diabetes and weight management

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