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While medications that reduce alcohol intake such as naltrexone and acamprosate have central nervous system action, disulfiram reduces alcohol intake through peripheral mechanisms

Materials and methods Chemicals CAP and N-(4-tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl) tetrahydropyrazine-1(2H)-carboxamide (BCTC) were purchased from SigmaAldrich (St

Thus, GLP-1 receptor agonists could attenuate the impact of alcohol withdrawal, with a positive impact in reducing relapsesa critical obstacle to dependency treatment

Orforglipron, expected to reach the market within 12-18 months, showed competitive results in Phase 3 trials with the added convenience of no food or water restrictions

[DOI] [PMC free article] [PubMed] [Google Scholar] 72.Fink J.M., Hetzenecker A., Seifert G., Runkel M., Laessle C., Fichtner-Feigl S., Marjanovic G

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