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Phase 3 protocols with slower titration are expected to improve tolerability

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Reconstituted AOD-9604 should be stored under refrigeration at 4 C (39 F) and used within the active research timeframe described in the Amount & Handling tab

Superimposing the structures of GCGRG s bound by GCG 4 , peptide 15 (GLP-1R and GCGR dual agonist) 28 and peptide 20 reveals that these three peptides adopt a similar binding pose: a single continuous helix that penetrates into the TMD core through their N-terminal halves (residues 1 to 15), while the C-terminal halves (residues 16 to 30) are recognized by the ECD, ECL1 and TM1 (Fig