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In March 2025, the FDA approved Sanofi/Alnylam Pharmaceuticals Qfitlia (fitusiran), an RNAi therapeutic to prevent or reduce the frequency of bleeding episodes in adult and paediatric patients (aged 12 years of age and over) with haemophilia A or B, with or without factor VIII or IX inhibitors

While semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist, metformin belongs to the drug class called biguanides

At 48 weeks, WL of 25% had occurred in 3648% of people with the 8 mg and 12 mg doses compared to no one who received placebo

Hajek T, Calkin C, Blagdon R, Slaney C, Uher R, Alda M

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it also elevates mortality rates associated with this condition (Martnez et al., 2006)