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Trial data show that patients who continue therapy tend to maintain their loss, while those who stop tend to regain a substantial portion which is why it is framed as a maintenance therapy, not a temporary course
Important caveat: the idea that a GHRH analog plus a ghrelin agonist produce additive or synergistic GH output is a reasonable hypothesis, but it has not been validated for this specific blend or its dosing

AL: Investigation, Methodology, Visualization, Writing original draft

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Since tirzepatide already activates the GLP-1 receptor along with the GIP receptor, combining it with semaglutide could overstimulate these pathways
