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Wang P, Alvarez-Perez JC, Felsenfeld DP, Liu H, Sivendran S, Bender A, et al (2015) A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication

Nonalcoholic steatohepatitis severity is defined by a failure in compensatory antioxidant capacity in the setting of mitochondrial dysfunction

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Weight loss appears to be more rapid in the first 10-12 weeks, but it continues to decrease at a slower rate thereafter (64)

By 2035 there will be 2bn obese individuals, and up to 4bn if one includes the overweight, a staggering 46% of the worlds population[2]