what mimics glp-1 receptor agonists TrimRX | GLP-1 vs GIP:
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Prescribing topiramate solely for weight loss is not supported by NICE guidance and falls outside standard UK clinical practice

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Dietary lipid infusion causes the release of chole-cystokinin, which acts both via vagus nerve afferents and directly in the brain to trigger activation of efferent vagus nerve signalling, which in turn suppresses the release of proinflammatory cytokines
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Clinical trials show people lost around 20% with Mounjaro on higher doses, around 15% with Wegovy, and around 8% with Saxenda
Nielsen, S
