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The GIP receptor activation appears to reduce nausea compared to pure GLP-1 agonists, which is why retatrutide shows a 28% nausea rate versus 44% for semaglutide despite being more potent

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The body has fully adapted to the metabolic changes, side effects are minimal or absent, and the improved nutrient partitioning operates consistently

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Abbreviations ADA: American Diabetes Association CV: Cardiovascular CVOTs: Cardiovascular outcome trials GLP-1RA: Glucagon-like peptide-1 receptor agonists HR: Hazard ratios MACE: Major cardiovascular events SGLT-2i: Sodiumglucose transporter-2 inhibitors T2DM: Type 2 diabetes mellitus References Giugliano D, Maiorino MI, Longo M, Bellastella G, Chiodini P, Esposito K