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Clinically, HO presents with rapid, refractory weight gain, hyperphagia, low energy expenditure, and impaired satiety, features often resistant to conventional lifestyle-based treatment

Garcia-Webb advises caution because you might not be getting the exact same medication that the pharmaceutical companies are selling, given that the FDA does not do rigorous safety checks on compounded meds

For this drug, the ongoing SOUL trial has shown promising preliminary results, indicating a 14% reduction in the risk of MACE (84)

Improper use may lead to unforeseen side effects or physiological disruptions

Switching for cardiovascular protection If the cardiovascular outcome data from the SELECT trial influenced your switch decision, the target formulation is typically Wegovy at 2.4 mg weekly

If you're experiencing side effects from Wegovy such as nausea, vomiting, diarrhoea, dehydration, or fatigue you should defer donation until you feel fully well , in line with NHSBT and JPAC guidance