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Most people describe the sensation as a slight pinch that lasts less than a second

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Patients receiving GLP-1s or other weight loss medications often report feeling fuller longer after meals and experiencing fewer urges to snack throughout the day

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This unique receptor activity makes tirzepatide a promising candidate for improving bone health in obesity and diabetes, through the positive effects of GIP, and potentially GLP-1, on bone metabolism

Stimulation of GLP-1 secretion downstream of the ligand-gated ion channel TRPA1