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In this context, data obtained from experimental studies are often inconsistent when compared with those conducted on humans, and many aspects require deeper investigations (e.g., role of DPP-4 in different cell types, temporal and spatial characteristics of DPP-4 expression across different disease stages, identification of possible ligands for DPP-4, and approaches for targeting nonenzymatic DPP-4 activity) [46,80]

Perceived stress mediates the relationship of body image and depressive symptoms in individuals with obesity

It can be difficult for many patients to lose weight using traditional methods such as dieting or exercise

More than 90% of SCFAs are absorbed by the gut or used by the microbiota (65)

Weight-based discrimination has been documented across multiple settings [[1], [2], [3], [4], [5], [6], [7]], with an average 15.5 % of women reporting discriminatory experiences due to weight/height in 20042006, a number that increased from 10 % in 19951996 and has continued to rise [8]