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Shiobara T, Chibana K, Watanabe T, et al
Mayo Clinics ENDO 2025 study of 120 postmenopausal women found tirzepatide plus HRT produced 17% weight loss vs 14% alone over 18 months, with 45% of HRT users hitting 20%+ loss vs 18% of non-users (see our tirzepatide vs semaglutide analysis)

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During GLP-1RA therapy, sustained hypophagia may further reduce effective micronutrient intake without immediately producing overt deficiency

doi: 10.1097/00004872-200306000-00012 94 KatsuradaKNakataMSaitoTZhangBMaejimaYNandiSSet al
