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In addition to its glucose-lowering and weight-loss effects, tirzepatide is currently undergoing Phase 3 or 4 clinical trials for other conditions, including obesity with osteoarthritis, atherosclerosis in T2DM patients, lipid metabolism and brain function in T2DM patients, and obstructive sleep apnea

doi: 10.1038/nn1908 195 TranP

Discovery of Intestinal Targeted TGR5 Agonists for the Treatment of Type 2 Diabetes
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Simply put, the more muscle you have, the more calories your body burns each day just to maintain basic functions like breathing and circulation
