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Knowing how Semaglutide actually functions helps patients set realistic expectations and recognize why it affects multiple systems at once

Given the high baseline depression incidence (14.8% annually), this translated to an absolute risk difference of 2.2% and a number needed to harm of 45 over 1 year

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Within 1 to 3 days, semaglutide activates GLP-1 receptors in your brain and digestive tract, signaling satiety and slowing stomach emptying

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This approach reflects lessons learned from earlier GLP-1 receptor agonists, where gastrointestinal side effects often limited compliance if higher doses were given immediately