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Updated NICE guidelines for type 2 diabetes: the place of GLP-1 RAs and tirzepatide In previous NICE guidance for type 2 diabetes, incretin mimetics were positioned as a later option for managing hyperglycaemia typically when triple oral therapy is ineffective, poorly tolerated or contraindicated, when BMI is sufficiently high, or when insulin needs to be avoided

Consider this my friendly reminder that your doctor is your best resource for medical advice and treatment decisions

Breast cancer can spread to lymph nodes in the armpit, so the arm can swell if theyre removed

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In pharmacology trials, GLP-1RA treatment has been shown to delay gastric emptying within the first postprandial hour [25, 28], although overall gastric emptying did not appear to be affected [28], suggesting additional mechanisms of action in GLP-1RA-mediated weight loss

demonstrated that semaglutide modulates the circulating proteome in individuals with overweight or obesity, with or without diabetes [67]