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A frozen pen is no longer effective and should be discarded immediately

Diabetes 57 , 26032612 (2008)

Serious but rare adverse effects include thyroid cancer, pancreatitis when the organ becomes inflamed and kidney failure
Dulaglutide offers another long-acting option, while Tirzepatide combines GIP and GLP-1 activity in a way that may enhance both weight management and glucose control

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