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Freedman DS, Butte NF, Taveras EM, Lundeen EA, Blanck HM, Goodman AB, et al

Compounding this plateau, placebo-controlled cardiovascular outcome trials (CVOTs) are increasingly deemed unethical in patients with established CVD, as current standards of care now include agents with proven cardiovascular efficacy, namely GLP-1RA and SGLT-2 inhibitors

11,12 Endopeptidase-catalyzed cleavage of GLP-1(137) generates two peptides with insulin secretagogue properties

One difference between the medicines is that the Wegovy pill must be taken on an empty stomach with a small amount of water, and patients are directed not to eat, drink or take other medicines for 30 minutes after taking it

HSA/FSA may be accepted