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Description
doi: 10.2337/diacare.27.6.1335
Over time, receptor sensitivity can decrease, a process called desensitization or downregulation
Phase 3 is testing specific doses to determine the optimal balance of efficacy and tolerability
SGLT2 inhibition leads to activation of lysosomal degradation and inhibition of mTOR, with possible changes in mitochondrial status followed by a switch in inflammatory events
What people are referring to as bad habits are reducing as well
Aim for at least 64 ounces per day, more if you exercise or live in a warm climate
