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Spironolactone targets the androgen pathway directly: Because PCOS is often marked by excess androgens, spironolactone can be a cornerstone therapy for both skin and confidence

Major depressive disorder was common in our population (4044 patients [22%] had a history in the preceding 2 years) suggesting clinical trials may have excluded many patients using these medications in clinical settings

Loreft B, Ganowiak W, Wissing U, Granrus AK, Unosson M

Full trial data is available at PubMed PMID 34170647

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