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In January 2025, the FDA approved Vertex Pharmaceuticals Journavx (suzetrigine) tablets, a first-in-class non-opioid analgesic for moderate-to-severe acute pain in adults

The SUSTAIN trial series followed patients for over two years, showing that continued therapy prevented weight regain when maintained consistently

The evolving landscape of obesity pharmacotherapy Nature Reviews Drug Discovery, 2026 1 Obesity pharmacotherapy has moved from weight loss drugs to cardiometabolic disease-modifying therapy Obesity is now framed as a chronic, relapsing, neuroendocrine-metabolic disease, not simply a lifestyle failure

Patients who want or need blood work can access Step One Labs panels, which start at approximately $95 for a basic panel, at the clinics referral pricing

Or someone who has perfectionism, or someone who's not getting enough physical activity

Gradual tapering over 48 weeks significantly reduces this rebound by allowing hunger hormones to normalize progressively rather than spiking suddenly