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The liver fat substudy data deserves its own discussion because metabolic dysfunction-associated steatotic liver disease (MASLD, formerly NAFLD) is one of the largest unmet needs in metabolic medicine, and there are few approved pharmacological interventions

Those Who Dropped to a Low Dose for Maintenance Study participants who reduced their dose to 5 mg regained a relatively small amount of weight (12 pounds, on average) compared with the total amount theyd lost over the prior 60 weeks (almost 54 pounds)

Since even a 5% to 10% reduction in body weight can bring benefits like improved cholesterol and blood pressure and reduced risk for conditions like obstructive sleep apnea, the impact of this degree of weight loss can be significant

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Over-the-counter GLP-1 patches do not contain semaglutide, tirzepatide, or any other prescription GLP-1 medication

According to a November 2025 KFF survey, more than half of GLP-1 users said the drugs were difficult to afford