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Unlike injections, oral GLP-1 medications must pass through the digestive system before being absorbed

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GLP-1 receptor agonists are synthetic drugs that mimic this hormone and stimulate its receptors in the brain and body

Serious adverse events and complications of these medications may include Gastroparesis (paralysis of the stomach), NAION vision loss, Ileus, Pancreatitis, Wernickes Encephalopathy, Bowel obstruction (blocked intestine), Malnutrition requiring hospitalization, and Pulmonary aspiration while under anesthesia or during surgery

Berberine alleviates intestinal barrier dysfunction in glucolipid metabolism disorder hamsters by modulating gut microbiota and gut-microbiota-related tryptophan metabolites

One important thing to keep in mind: people in these studies were also making changes to how they were eating and moving