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GPR40 is primarily expressed by the pancreatic -cells, where it plays a pivotal role in FFA-mediated insulin secretion (249) but also in -cells (78, 250), CCK (80), GIP (251), and GLP-1 (79) producing cells in the gut and in hypothalamic neurons (248, 252, 253)

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If the solution is still difficult to draw, ensure that the needle is correctly inserted into the vial and that the vial is at an appropriate angle

What made exendin-4 particularly interesting was its resistance to degradation in the body and its longer-lasting effects compared to native human GLP-1

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Lotte Bjerre Knudsen , a distinguished scientist at Novo Nordisk, led efforts to translate the discovery of GLP-1 into a viable therapeutic option