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Many people who suffer from obesity find it hard to lose weight and keep it off with just diet and exercise

Clinicians should judiciously balance potential benefits against risks when considering the use of these agents in pregnant patients and, where feasible, engage in thorough preconception counseling.225,226 Future research should prioritize the evaluation of long-term safety outcomes during pregnancy and potential fetal effects to inform safer clinical practices

Pramlintide uses three proline substitutions (positions 25, 28, 29: Ala25Pro, Ser28Pro, Ser29Pro) derived from rat amylin (naturally non-amyloidogenic) to disrupt beta-sheet formation

took place without restrictions

Whilst emerging evidence suggests potential mood benefits, GLP-1 agonists are not without adverse effects, and mental health monitoring remains important during treatment

This can lead to fatigue and daytime sleepiness