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Finally, if weight regain occurs (typically defined as regaining more than 35% of lost weight), prompt consultation allows for early intervention before significant regain undermines previous progress

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If patients experience a sustained increase in resting heart rate while taking tirzepatide, the drug should be discontinued

This adaptive response is ancient biology working against modern goals

Patients should inform healthcare providers about all supplements, including vitamins, minerals, herbs, and over-the-counter products, as comprehensive medication reconciliation is essential for safe tirzepatide therapy

Sensitivity analysis Four different sensitivity analyses were conducted to assess the findings of the primary analysis (Table 3)