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[DOI] [PMC free article] [PubMed] [Google Scholar] 122.Mellbin L.G., Bhatt D.L., David J.P., Ekstrm K., Petrie M.C., Rasmussen S., Vilsbll T

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7 As the first approved dual agonist targeting both GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptors, tirzepatide demonstrated weight loss exceeding 20% in its pivotal trials, establishing a new therapeutic ceiling

However, in vitro, evidence suggests that hyperglycemia, a primary metabolic feature of T2DM, can lead to impaired GLP-1 secretion and L-cell differentiation
