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Subsequently, we analyzed the body weight change over trial period from four participant groups: females with baseline leptin above 29.3ng/ml (female High-Lep , N=53) and below 29.3ng/ml (female Low-Lep , N=53), males with baseline leptin above 10.5ng/ml (male High-Lep , N=59) and below 10.5ng/ml (male Low-Lep , N=58)

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In addition, a further analysis of the STEP 14 studies showed that weight loss was associated with an improvement in health-related quality of life [104]

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Table 1 Gut microbiota-derived metabolites and associated genera or species in IBS

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