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Mazdutide is also further along on the regulatory side, with an approval already in place in China, while retatrutide remains investigational everywhere

These guidelines emphasize that obesity medications should be continued as long as they remain effective, are well-tolerated, and the benefits outweigh risks

10.1016/j.diabres.2018.02.026 [EL 1

Yang L, Wang H, Liu L, Xie A

In contrast, liraglutide was associated with increased coronary artery fibrous plaque volume in asymptomatic T2D patients without prior coronary artery disease, suggesting mixed outcomes 16

Apart from increasing the binding affinity of GLP-1, compound 2 also acts as an agonist on its own, thereby being classified as an ago-allosteric modulator (ago-PAM) of GLP-1R 25,28
