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In the sensitivity analysis, the rates of major birth defects, when all major anomalies irrespective of aetiology were included, were 3.1% in the GLP1-RA exposed group and 4.2% in the reference group with diabetes

The SURPASS-CVOT trial (NCT04255433) will assess the cardiovascular safety of tirzepatide compared to dulaglutide in people with T2D and established atherosclerotic disease [111]

Tirzepatide: The Dual-Receptor Innovation Tirzepatide represents the next generation of weight loss medication

ArticlePubMed 29

This heart rate elevation is believed to be mediated by direct GLP-1 receptor activation in the sinoatrial node and by sympathetic nervous system activation
