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In SURMOUNT-5, once weekly tirzepatide at the maximum tolerated dose (MTD 10 mg or 15 mg) compared with semaglutide (MTD 1.7 mg or 2.4 mg) resulted in significantly greater body weight reduction in adults living with obesity without T2D
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per-protocol HR 0.60
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Recent breakthroughs highlighted the dramatic effect of GLP-1RAs and related pharmaceuticals in reversing the effects imposed by metabolic syndrome on cardiovascular health.
