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Additionally, researchers use preclinical models to examine how the metabolic effects of dual gastric inhibitory polypeptide (GIP)/GLP-1R agonists such as tirzepatide mediate anti-inflammatory and anti-fibrotic benefits, such as in metabolic dysfunction-associated steatotic liver disease
Despite their considerable benefits, GLP-1 RAs are associated with various adverse reactions (Fig
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doi:10.1056/NEJMoa1501352
Eli Lilly has seven additional Phase 3 TRIUMPH trials expected to complete during the course of the coming months and into the following year
