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To determine whether the reduction in HGP observed following the deletion of Dpp4 from the whole animal or liver only can prevent NAFLD progression, we fed aged 6-month-old mice either a standard laboratory diet (SLD) or an HFHC diet for 24 weeks

The hormone GLP-1 can help lower blood sugar levels in people with type 2 diabetes by triggering a gland called the pancreas to release insulin

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The substitution of Ala8 in GLP-1 by Gly8 in exendin-4 contributes to enhanced DPP-4 resistance ( Interestingly, until now, primarily long-chain peptides with 3339 amino acids have been developed as GLP-1RAs, which also carry a cost burden

Measurement of size and turnover rate of body glucose pool by the isotope dilution method