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Accordingly, the renal effects of RAAS blockade do not seem to explain the observed changes in ADC in the empagliflozin and semaglutide groups

Possible reasons can be several fold, including blunted response to pain medication in patients with metabolic disease and potential timing of restarting GLP-1s following surgery, according to Prather

[DOI] [PMC free article] [PubMed] [Google Scholar] 120.Wang Z.J., Li X.R., Chai S.F., Li W.R., Li S., Hou M., Li J.L., Ye Y.C., Cai H.Y., Hlscher C., et al

And, so far, while quality and safety inspections and enforcement typical among compounders are occurring with compounders of GLP-1 products, we have not seen evidence publicly that the FDA is taking action specifically against the practice of compounding GLP-1 products that are no longer in shortage as products that are essentially a copy of the FDA-approved products

In summary: the study provides highly relevant evidence as a starting point toward personalized medicine in obesity