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These therapies are expected to offer greater efficacy and potentially target multiple metabolic pathways, providing improved outcomes for weight loss and related comorbidities like mazdutide, retatrutide, and survodutide [36, 37]

Nonetheless, residual effects on gastric emptying could still produce significant gastrointestinal adverse effects in patients treated with long-acting GLP-RAs (167)

[51] Vickers, S

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In animal studies, GLP1-agonists were associated with reduced fetal weight and/or growth, delayed ossification and skeletal variants, usually associated with a reduction in maternal weight gain and decreased food consumption