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doi: 10.1126/science.abd2985 75 MayiBSLeibowitzJAWoodsATAmmonKALiuAERajaA

95% CI, 0.820.92).[21] Another study revealed that semaglutide and tirzepatide were promising potential therapies in patients with obesity and comorbid alcohol use disorder,[56, 57] and dulaglutide use for smoking cessation did not improve tobacco abstinence but did reduce alcohol consumption.[58, 59] Studies of exenatide reported improved smoking cessation outcomes, though no benefit was observed for cocaine or alcohol use.[6062] A comparative study found semaglutide associated with a significantly lower hazard ratio for nicotine use versus sitagliptin, empagliflozin, and glipizide.[63] Additional GLP-1RA uses Emerging off-label indications for GLP-1RAs continue to be identified, with future research potentially establishing a basis for their extended therapeutic application in a range of medical conditions

Monthly persistency erosion is steeper in obesity: Obesity GLP-1s drop to 32% persistence over 13 months, compared to 41% for diabetes

Strategies for Maintaining Long-Term GLP-1 Safety Several practical strategies can help maintain the long-term safety and tolerability of GLP-1 therapy while improving adherence

Time injections thoughtfully based on your schedule and how your body responds

ReadyRx also provides a toggle option between compounded and branded versions, which is uncommon among telehealth-only platforms and adds flexibility for users who may be able to access insurance coverage for the branded versions