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Nausea is the most common side effect , reported by approximately 20% of patients in clinical trials

In a combined analysis of three trials with 1,119 participants, individuals with PAM variants responded less effectively to GLP-1 drugs and were less likely to reach target HbA1c levels, a measure of long-term blood sugar control

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This is because orforglipron is a small molecule absorbed through passive diffusion in the small intestine, rather than a peptide requiring the SNAC absorption enhancer and stomach-specific absorption conditions needed by Rybelsus

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