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Large-scale, placebo-controlled randomized clinical trials specifically designed for psychiatric populations are critically needed to determine the efficacy, optimal dosing, duration, and long-term safety of GLP-1 RAs in treating mood symptoms [101]

A 40-week clinical trial involving 1,800 participants compared type 2 diabetes treatment with tirzepatide and semaglutide and found similar results

Short-acting agents may have more persistent meal-to-meal gastric-emptying effects, while long-acting agents may show attenuation of this effect over time

However, clinical data specifically evaluating their concurrent use are lacking, so theoretical considerations and individual patient factors must guide decision-making with healthcare provider input

Because Medicaid is jointly financed by the states and the federal government, CMS estimated the federal government would pay $11 billion of that total