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Current research demonstrates that AMPK pathway activation serves as the primary metabolic mechanism, while nuclear translocation and gene regulation provides stress-responsive control

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[DOI] [PubMed] [Google Scholar] 19.Lebrun L.J., Lenaerts K., Kiers D., Pais de Barros J.P., Le Guern N., Plesnik J., Thomas C., Bourgeois T., Dejong C.H., Kox M., et al

Cardiovascular outcome trials (CVOTs) have demonstrated that GLP1R agonists reduce the rates of major adverse cardiovascular events in patients with T2DM