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Consult your provider: Always follow your prescriber's instructions

If non-drowsy antihistamines are not effective enough, taking diphenhydramine 25mg about 30 to 60 minutes before your injection, preferably in the evening, provides stronger histamine blockade

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By activating GLP-1 receptors, tirzepatide enhances glucose-dependent insulin secretion from pancreatic beta cells, suppresses inappropriately elevated glucagon secretion, and slows gastric emptying