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These side effects may include: vomiting nausea diarrhea constipation bloating gas and belching heartburn stomach flu dehydration, especially in people with kidney failure More serious side effects may include: pancreatitis (inflammation of the pancreas) severe stomach problems GLP-1 agonists are approved for people with type 2 diabetes to manage their blood sugar levels, and some are approved for weight loss

The phase 3 TRIUMPH-4 trial confirmed these findings

Increasing prevalence of obesity and related chronic conditions like diabetes and cardiovascular diseases is one such prominent growth driver

Although investigational methods such as intranasal or inhaled formulations are still in their initial development phase, they illustrate a widespread initiative to develop alternatives to injection-based treatments

Zepbound produces roughly 50% more weight loss but costs about 75% more

A phase 2, 16-week, open-label study in 18 subjects ranging from 6 to 40 years of age results in a mean BMI reduction of 18% in those younger than 18 years, and 6% for those 18 years or older, accompanied by significant reduction of hunger scores (127)