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Semaglutide is generally recommended for people with a body mass index over 27 and comorbidities such as diabetes, hypertension, joint problems, depression, and anxiety

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Indeed, further electrophysiological studies demonstrated that exendin-4 predominantly activates presynaptic GLP-1R in NAc to increase the frequency of AMPA/kainate receptor-mediated mEPSCs

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This no-reflow is associated with reduced left ventricular ejection fraction, increased infarct size and death