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Intriguingly, a recent study has confirmed that GLP-1R acts as a negative co-stimulatory molecule on T cells

Weight typically regains (about two-thirds of lost weight within a year)
Preda A, Montecucco F, Carbone F, et al

Comparison of the independent and combined effects of sub-chronic therapy with metformin and a stable GLP-1 receptor agonist on cognitive function, hippocampal synaptic plasticity and metabolic control in high-fat fed mice

[DOI] [PMC free article] [PubMed] [Google Scholar] 480.Giugliano, D
doi: 10.1016/s0026-0495(99)90232-9
