glp 1 agonist and pregnancy Preconception use of GLP-1 GLP-1/GIP receptor agonists for obesity treatment GLP-1s (Weight loss injections) AND

Multiple randomized controlled trials and meta-analyses have examined hepatic endpoints in patients with type 2 diabetes and NAFLD

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Metabolism 2010;59:123-133

This may be related to the mechanism of action of GLP-1RA drugs

And small peptide GLP-1 analogues have been demonstrated to cross BBB via peripheral administration, including LG, lixisenatide and exendin-4 (72)

The early deterioration of diabetic retinopathy observed with GLP-1 RAs may reflect rapid glucose decline that affects osmotic pressure rather than direct retinal toxicity [91]