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The former reflects a proportional decrease in lean tissue during negative energy balance and is typically expected to account for roughly one-quarter of the total weight loss, whereas the latter involves both quantitative loss of skeletal muscle and impaired muscle function or strength [19]

Lets take a closer look at these groups: Oral GLP-1 drugs While most GLP-1 drugs are injectables, oral options are also available

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GLP-1-induced intra-islet insulin secretion may locally inhibit glucagon secretion

Advantage : Semaglutide Glycemic Control# Orforglipron : ACHIEVE-3 showed orforglipron 36 mg reduced HbA1c by 2.2% at 52 weeks, superior to oral semaglutide 14 mg (1.4% reduction)

Muscle loss on GLP-1s isn't inevitable