retatrutide liver Retatrutide, the triple G, Glucagon-GIP-GLP-1 based triagonist produces substantial resolution of fat #NAFLD in PPL with #obesity #ADA2023 @ADA_DiabetesPro @AmDiabetesAssn #NASH trial coming Retatrutide vs Tirzepatide (2026): Differences
Description
Diabetes Metab J 44(6):80218 Coskun T, Urva S, Roell WC, Qu H, Loghin C, Moyers JS et al (2022) LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: from discovery to clinical proof of concept
BMJ 372, m457314
The most common options are single-hormone GLP-1 and dual-action GLP-1 + GIP medications
18 612 months: Sustained hormone improvements
Mechanism Gastric emptying results from a sophisticated interaction between gastric pacemaker cells, gastrointestinal smooth muscle dynamics, and neurohormonal regulatory mechanisms
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