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To detect GLP-1R activity in the ex-vivo assay over a sufficient period of time for accurate half-life determination, the dose of the glycosylated variant in the PK stability experiment had to be increased to 40 mg/kg compared to 5 mg/kg for the non-glycosylated fusion

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For most healthy adults, these changes remain within acceptable ranges

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Glucagon-like peptide-1 receptor (GLP-1R) belongs to the B family of G protein-coupled receptors (GPCRs)