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Gastrointestinal discomfort, including nausea, vomiting, diarrhea, and abdominal pain, is a common side effect of GLP-1 receptor agonists
Most studies demonstrated a low risk in key domains, such as the randomization process and missing outcome data, indicating a robust trial design and adequate follow-up
All in all, the placebo group fared far worse than those on orforglipron
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Sources: Diab H, Fuquay T, Datta P, Bickel U, Thompson J, Krutsch K
doi: 10.1016/j.jcjd.2019.05.005 38 ChoiJGWinnANSkandariMRFrancoMIStaabEMAlexanderJet al
A review on latent autoimmune diabetes in adults
