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Although other trials, for example the SUSTAIN 6 trial evaluating semaglutide for potential cardiovascular benefits in patients with type 2 diabetes, did not find a sex difference in the rate of reported GI events (51% more than placebo in men, 47% more than placebo in women) or in the rate of treatment discontinuation due to adverse events (76% more than placebo in men, 127% more than placebo in women)

These activated PBN neurons project to VMH neurons and cause counterregulatory response (CRR), thereby stimulating glucose production and inhibiting glucose uptake to restore normal blood glucose levels in the hypoglycemic state [73, 74]

The primary endpoint occurred in 569 of 8803 participants (6.5%) in the semaglutide group compared with 701 of 8801 participants (8.0%) in the placebo group, corresponding to an HR of 0.80 (95% CI, 0.720.90

10.1007/s00535-015-1055-2 71 NakamuraA.KomatsuM.OhnoY.NoguchiN.KondoA.HatanoN

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