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However, the 503A pathway has its own legal limitations that have tightened since 2025

"The important factor is that some weight was not regained, and when you look at the loss from baseline weight, it's about 4% to 5% of the baseline weight that was lost and maintained

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The Bottom Line Weight loss is a common goal for new moms, but the safety of GLP-1 drugs like semaglutide during breastfeeding is still not fully understood

These combined actions make semaglutide an effective medication for managing diabetes and supporting weight loss

Edema persists beyond the expected resolution window (8 to 12 weeks)