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Common First-Dose Side Effects and When They Peak Nausea is the most frequently reported side effect after the first semaglutide injection, typically appearing 24 to 48 hours post-injection and often peaking around day two or three

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Data accumulated from animal experiments conducted in acute ischemic stroke models with and without diabetes have also demonstrated a dose-dependent reduction of infarct volume in the brain by GLP-1RAs, when administered before or during the acute phase of ischemia at reperfusion or with some delay after the onset of reperfusion [60,61,62, 70]

If you're considering a treatment pause, discuss it with your PlexusDx provider to plan a tapering strategy rather than abrupt discontinuation

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